synergistic interactions of methanolic extract of acacia mearnsii de wild. with antibiotics against bacteria of clinical relevance协同交互methanolic提取的黑德野生。.pdfVIP

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synergistic interactions of methanolic extract of acacia mearnsii de wild. with antibiotics against bacteria of clinical relevance协同交互methanolic提取的黑德野生。.pdf

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synergistic interactions of methanolic extract of acacia mearnsii de wild. with antibiotics against bacteria of clinical relevance协同交互methanolic提取的黑德野生。

Int. J. Mol. Sci. 2012, 13, 8915-8932; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Synergistic Interactions of Methanolic Extract of Acacia mearnsii De Wild. with Antibiotics against Bacteria of Clinical Relevance Olufunmiso O. Olajuyigbe and Anthony J. Afolayan * Phytomedicine Research Centre, Department of Botany, University of Fort Hare, Alice 5700, South Africa; E-Mail: funmijuyigbe12@ * Author to whom correspondence should be addressed; E-Mail: aafolayan@ufh.ac.za; Tel.: +27-822-022-167; Fax: +27-866-282-295. Received: 27 March 2012; in revised form: 27 June 2012 / Accepted: 10 July 2012 / Published: 17 July 2012 Abstract: With the emergence of multidrug-resistant organisms, combining medicinal plants with synthetic or orthodox medicines against resistant bacteria becomes necessary. In this study, interactions between methanolic extract of Acacia mearnsii and eight antibiotics were investigated by agar diffusion and checkerboard assays. The minimum inhibitory concentrations (MICs) of all the antibiotics ranged between 0.020 and 500 µg/mL while that of the crude extract varied between 0.156 and 1.25 mg/mL. The agar diffusion assay showed that extract-kanamycin combination had zones of inhibition ≥20 ± 1.0 mm in all the bacteria tested (100%), followed by extract-chloramphenicol (90%) extract-ciprofloxacin = extract-te