原创力文档synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features滑膜细胞因子表达与淋巴银屑病关节炎和协会再生和临床特征.pdfVIP
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synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features滑膜细胞因子表达与淋巴银屑病关节炎和协会再生和临床特征
Celis et al. Arthritis Research Therapy 2012, 14:R93
/content/14/2/R93
RESEARCH ARTICLE Open Access
Synovial cytokine expression in psoriatic arthritis
and associations with lymphoid neogenesis and
clinical features
1 2 3 1 1 4
Raquel Celis , Núria Planell , José L Fernández-Sueiro , Raimon Sanmartí , Julio Ramírez , Isidoro González-Álvaro ,
José L Pablos5 and Juan D Cañete1*
Abstract
Introduction: Psoriatic arthritis (PsA) is an autoantibody-negative immune-mediated disease in which synovial
lymphoid neogenesis (LN) occurs. We determined whether LN is associated with specific patterns of inflammatory
cytokine expression in paired synovial tissue (ST) and fluid (SF) samples and their potential correlation with the clinical
characteristics of PsA.
Methods: ST and paired SF samples were obtained from the inflamed knee of PsA patients. ST samples were
immunostained with CD3 (T cell), CD20 (B cell), and MECA-79 (high endothelial vessels). Total ST mRNA was extracted,
and the gene expression of 21 T-cell-derived and proinflammatory cytokines were measured with quantitative real-time
PCR. SF concentrations of Th1, Th2, Th17, and proinflammatory cytokines were determined with the Quantibody
Human Th17 Array. Clinical and biologic data were collected at inclusion and after a median of 27 months of follow-up.
Results: Twenty (43.5%) of 46 patients had LN. Only two genes showed differences (Wilcoxon test, P 0.06) in ST
between LN-positive and LN-negative patients: interleukin-23A (IL-23A) (P = 0.058) and transforming growth factor-
beta (TGF-b 1) (P = 0.050). IL-23A expression was higher, and TGF-b 1 expression was lower in LN-positive patients.
ST IL-15 mRNA showed a nonsignificant trend
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