synthetic biology advancing biological frontiers by building synthetic systems通过构建合成系统合成生物学前沿生物.pdfVIP

Chen et al. Genome Biology 2012, 13:240 /2012/13/2/240 R E V I E W Synthetic biology: advancing biological frontiers by building synthetic systems 1,2,† 3,† 4 Yvonne Y Chen , Kate E Galloway and Christina D Smolke* feedback circuits) and new frontiers in health and medi- Abstract cine (such as identification of diseased cells and targeted Advances in synthetic biology are contributing therapeutics). to diverse research areas, from basic biology to biomanufacturing and disease therapy. We discuss the Conceptual frameworks for biological design theoretical foundation, applications, and potential of A central aim of synthetic biology is to increase the ease this emerging eld. and efficiency with which biological systems can be designed, constructed, and characterized. Although the manipulation of biological organisms and molecular Synthetic biology is an emerging field of interdisciplinary pathways long preceded the emergence of synthetic research that seeks to transform our ability to probe, biology, the engineering of biological systems has been a manipulate, and interface with living systems by largely ad hoc exercise. A main reason is that biology is combining the knowledge and techniques of biology, inherently diverse, mutable, and context specific. Natural chemistry, co