原创力文档synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint在银屑病关节炎滑膜积液和滑液生物标志物来评估intraarticular膝关节肿瘤坏死factor-α封锁.pdfVIP
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synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint在银屑病关节炎滑膜积液和滑液生物标志物来评估intraarticular膝关节肿瘤坏死factor-α封锁
Fiocco et al. Arthritis Research Therapy 2010, 12:R148
/content/12/4/R148
RESEARCH ARTICLE Open Access
Synovial effusion and synovial fluid biomarkers in
psoriatic arthritis to assess intraarticular tumor
necrosis factor-a blockade in the knee joint
1* 1 1 2 3 1
Ugo Fiocco , Paolo Sfriso , Francesca Oliviero , Pascale Roux-Lombard , Elena Scagliori , Luisella Cozzi ,
Francesca Lunardi3 3 1 1 1 1
, Fiorella Calabrese , Maristella Vezzù , Serena Dainese , Beatrice Molena , Anna Scanu ,
4 3 5 1
Roberto Nardacchione , Leopoldo Rubaltelli , Jean Michel Dayer , Leonardo Punzi
Abstract
Introduction: The purpose of this study was theevaluation of synovial effusion (SE), synovial fluid (SF) and synovial
tissue (ST) biomarkers in relation to disease activity indexes to assess the response to intraarticular (IA) tumor
necrosis factor (TNF)-a blockers in psoriatic arthritis (PsA).
Methods: Systemic and local disease activity indexes (disease activity score (DAS); the Ritchie articular index (mRAI),
erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP); Thompson articular (THOMP) and joint articular
(KJAI)-Index ) and ST samples were assessed at baseline, throughout treatment, and during the follow-up in 14
patients affected with PsA who underwent IA injections (0.5 ml to 12.5 mg) in the knee joint of etanercept (E) or
placebo (P) once every two weeks for a 10-week period. Total SF white blood cell (WBC) counts (WBC/μl) and SF
cytokine/chemokine (CK/CCK) levels were measured before IA
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