synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes关节炎患者滑膜微粒synoviocytes调节趋化因子和细胞因子释放.pdfVIP

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synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes关节炎患者滑膜微粒synoviocytes调节趋化因子和细胞因子释放.pdf

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synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes关节炎患者滑膜微粒synoviocytes调节趋化因子和细胞因子释放

Available online /content/7/3/R536 Vol 7 No 3 Open Access Research article Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes 1 1 2 1 2 René J Berckmans , Rienk Nieuwland , Maarten C Kraan , Marianne CL Schaap , Desirée Pots , 2 1 2 Tom JM Smeets , Augueste Sturk and Paul P Tak 1Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 2Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Corresponding author: René J Berckmans, r.j.berckmans@amc.nl Received: 13 Oct 2004 Revisions requested: 1 Nov 2004 Revisions received: 26 Jan 2005 Accepted: 2 Feb 2005 Published: 1 Mar 2005 Arthritis Research Therapy 2005, 7:R536-R544 (DOI 10.1186/ar1706) This article is online at: /content/7/3/R536 © 2005 Berckmans et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Synovial fluid from patients with various arthritides contains intracellular adhesion molecule-1 (ICAM-1) were determined. procoagulant, cell-derived microparticles. Here we studied Results were consistent with previous observations: synovial whether synovial microparticles modulate