synovial expression of il-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor在类风湿性关节炎滑膜表达il-15并不受封锁的肿瘤坏死因子的影响.pdfVIP
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synovial expression of il-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor在类风湿性关节炎滑膜表达il-15并不受封锁的肿瘤坏死因子的影响
Available online /content/8/1/R18
Vol 8 No 1 Open Access
Research article
Synovial expression of IL-15 in rheumatoid arthritis is not
influenced by blockade of tumour necrosis factor
1 2 2 3 2
Sofia Ernestam , Erik af Klint , Anca Irinel Catrina , Erik Sundberg , Marianne Engström ,
Lars Klareskog2 and Ann-Kristin Ulfgren2
1Department of Rheumatology, Karolinska University Hospital, S-141 86 Stockholm, Sweden
2Department of Medicine, Rheumatology Unit, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden
3Department of Women and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet/Karolinska University Hospital, Stockholm,
Sweden
Corresponding author: Sofia Ernestam, sofia.ernestam@karolinska.se
Received: 8 Jul 2005 Revisions requested: 16 Aug 2005 Revisions received: 6 Oct 2005 Accepted: 21 Nov 2005 Published: 28 Dec 2005
Arthritis Research Therapy 2006, 8:R18 (doi:10.1186/ar1871)
This article is online at: /content/8/1/R18
© 2005 Ernestam et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Blockade of tumour necrosis factor (TNF) is an effective analysis. IL-15 expression was detected in all synovial biopsies
treatment in rheumatoid arthritis (RA), but both non-responders taken at baseline. After infliximab therapy, the expression of IL-
and partial responders are quite fre
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