原创力文档synthetic geopolymers for controlled delivery of oxycodone adjustable and nanostructured porosity enables tunable and sustained drug release综合地质聚合物对羟考酮可调节和控制纳米孔隙度使可调、持续的药物释放.pdfVIP
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synthetic geopolymers for controlled delivery of oxycodone adjustable and nanostructured porosity enables tunable and sustained drug release综合地质聚合物对羟考酮可调节和控制纳米孔隙度使可调、持续的药物释放
Synthetic Geopolymers for Controlled Delivery of
Oxycodone: Adjustable and Nanostructured Porosity
Enables Tunable and Sustained Drug Release
˚
Johan Forsgren, Christian Pedersen, Maria Strømme*, Hakan Engqvist
Department of Engineering Sciences, Uppsala University, Uppsala, Sweden
Abstract
In this article we for the first time present a fully synthetic mesoporous geopolymer drug carrier for controlled release of
opioids. Nanoparticulate precursor powders with different Al/Si-ratios were synthesized by a sol-gel route and used in the
preparation of different geopolymers, which could be structurally tailored by adjusting the Al/Si-ratio and the curing
temperatures. In particular, it was shown that the pore sizes of the geopolymers decreased with increasing Al/Si ratio and
that completely mesoporous geopolymers could be produced from precursor particles with the Al/Si ratio 2:1. The
mesoporosity was shown to be associated with a sustained and linear in vitro release profile of the opioid oxycodone. A
clinically relevant release period of about 12 h was obtained by adjusting the size of the pellets. The easily fabricated and
tunable geopolymers presented in this study constitute a novel approach in the development of controlled release
formulations, not only for opioids, but whenever the clinical indication is best treated with a constant supply of drugs and
when the mechanical stability of the delivery vehicle is crucial.
Citation: Forsgren J, Pedersen C, Strømme M, Engqvist H (2011) Synthetic Geopolymers for Controlled Delivery of Oxycodone: Adjustable and Nanostructured
Porosity Enables Tunable and Sustained Drug Release. PLoS ONE 6(3): e17759. doi:10.1371/journal.pone.0017759
Editor: Joel Schnu
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