synthetic polymer scaffolds for stem cell transplantation in retinal tissue engineering合成聚合物支架的干细胞移植视网膜组织工程.pdfVIP

Polymers 2011, 3, 899-914; doi:10.3390/polym3020899 OPEN ACCESS polymers ISSN 2073-4360 /journal/polymers Review Synthetic Polymer Scaffolds for Stem Cell Transplantation in Retinal Tissue Engineering Jing Yao 1,2, Sarah L. Tao 3 and Michael J. Young 2,* 1 Department of Ophthalmology, Eye ENT Hospital, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai 200031, China 2 Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA; E-Mail: jing.yao@ 3 The Charles Stark Draper Laboratory, Inc., 555 Technology Square, MS37 Cambridge, MA 02139, USA; E-Mail: stao@ * Author to whom correspondence should be addressed; E-Mail: michael.young@; Tel.: +1-617-912-7419; Fax: +1-617-912-0101. Received: 17 April 2011; in revisedform: 23 May 2011 / Accepted: 25 May 2011 / Published: 26 May 2011 Abstract: Age-related macular degeneration and retinitis pigmentosa are two leading causes of irreversible blindness characterized by photoreceptor loss. Cell transplantation may be one of the most promising approaches of retinal repair. However, several problems hinder the success of retinal regeneration, including cell delivery and survival, limited cell integration and incomplete cell differentiation. Recent studies show that polymer scaffolds can address these three problems. This article reviews the current literature on synthetic polymer scaffolds used for stem cell transplantation, especially retinal progenitor cells. The advantages and disadvantages