synthesis, structure and antifungal activity of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3h)-ones合成、结构和抗真菌活性的新3 -((5-aryl-1 3 4-oxadiazol-2-yl)甲基)苯并[d]thiazol-2(3 h)的.pdfVIP

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synthesis, structure and antifungal activity of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3h)-ones合成、结构和抗真菌活性的新3 -((5-aryl-1 3 4-oxadiazol-2-yl)甲基)苯并[d]thiazol-2(3 h)的.pdf

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synthesis, structure and antifungal activity of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3h)-ones合成、结构和抗真菌活性的新3 -((5-aryl-1 3 4-oxadiazol-2-yl)甲基)苯并[d]thiazol-2(3 h)的

Molecules 2012, 17, 989-1001; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl- 1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones Jian-Quan Weng 1,*, Xing-Hai Liu 1, Hua Huang 1, Cheng-Xia Tan 1 and Jie Chen 2 1 College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China; E-Mails: xhliu@ (X.-H.L.); chaohuhuanghua@126.com (H.H.); tanchengxia@ (C.-X.T.) 2 Department of Bioassay, Zhejiang Branch of National Southern Pesticide Research Centre, Hangzhou 310023, China; E-Mail: chenjie01@ * Author to whom correspondence should be addressed; E-Mail: jqweng@; Tel.: +86-571-8832-0220; Fax: +86-571-8832-0220. Received: 7 December 2011; in revised form: 6 January 2012 / Accepted: 9 January 2012 / Published: 18 January 2012 Abstract: A series of new 3-[(5-aryl- 1,3,4-oxadiazol-2-yl)methy])benzo[d]thiazol-2(3H)-ones were synthesized by reaction of (5-substituted-2-oxobenzothiazolin-3-yl)-acetohydrazide with various aromatic acids in POCl3 under reflux conditions. The structures of the title compounds were confirmed by 1H-NMR, 13C-NMR, IR, MS and elemental analysis. Furthermore, the structure of compound 4i was determined by single-crystal X-ray diffraction. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizocton