synthetic approaches and biological activities of 4-hydroxycoumarin derivatives4-hydroxycoumarin衍生物的合成方法和生物活性.pdfVIP

下载本文档

3
0
约5.45万字
约 14页
2017-09-12 发布于上海
举报
版权申诉

synthetic approaches and biological activities of 4-hydroxycoumarin derivatives4-hydroxycoumarin衍生物的合成方法和生物活性.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthetic approaches and biological activities of 4-hydroxycoumarin derivatives4-hydroxycoumarin衍生物的合成方法和生物活性

Molecules 2009, 14, 4790-4803; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Synthetic Approaches and Biological Activities of 4-Hydroxycoumarin Derivatives Jae-Chul Jung 1 and Oee-Sook Park 2,* 1 Ewha Global Challenge, BK21 and Medical Research Institute, School of Medicine, Ewha Womans University, Seoul 158–710, Korea; E-Mail: jcjung10@yahoo.co.kr (J.-C.J.) 2 Department of Chemistry, Institute for Basic Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 361–763, Chungbuk, Korea * Author to whom correspondence should be addressed; E-Mail: ospark@cbnu.ac.kr. Received: 19 October 2009; in revised form: 16 November 2009 / Accepted: 18 November 2009 / Published: 23 November 2009 Abstract: The main purpose of this review is to summarize recent chemical syntheses and structural modifications of 4-hydroxycoumarin and its derivatives, of interest due to their characteristic conjugated molecular architecture and biological activities. Keywords: 4-hydroxycoumarin; anticoagulant; rodenticide; ring cyclization; tetralone; coupling reaction 1. Introduction 4-Hydroxycoumarins (2H-1-benzopyran-2-ones, Figure 1) have evoked a great deal of interest due to their biological properties and characteristic conjugated molecular architecture. Many of them display important pharmacological effects, including analgesic [1], anti-arthritis [2], anti-inflammatory [3], anti-pyretic [4], anti-bacterial [5], anti-viral [6], and anti-cancer [7] properties. 4-Hydroxy-