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The Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age- Related Macular Degeneration Huiyi Chen, Bin Liu, Thomas J. Lukas, Arthur H. Neufeld* Forsythe Laboratory for the Investigation of the Aging Retina, Department of Ophthalmology, Northwestern University School of Medicine, Chicago, Illinois, United States of America Abstract Background: Although the statement that age is the greatest risk factor for Age-related macular degeneration (AMD) is widely accepted, the cellular and molecular explanations for that clinical statement