the anti-tumorigenic mushroom agaricus blazei murill enhances il-1β production and activates the nlrp3 inflammasome in human macrophagesanti-tumorigenic蘑菇双blazei murill增强il-1β生产和激活nlrp3 inflammasome人类巨噬细胞.pdfVIP

The Anti-Tumorigenic Mushroom Agaricus blazei Murill Enhances IL-1b Production and Activates the NLRP3 Inflammasome in Human Macrophages 1,2,3,4 1,5 1,3,6,7 8 7 Tsung-Teng Huang , David M. Ojcius , John D. Young , Yi-Hui Wu , Yun-Fei Ko , Tsui- 1,3,4 1,3,4 9 1,2,4 Yin Wong , Cheng-Yeu Wu , Chia-Chen Lu , Hsin-Chih Lai * 1 Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China, 2 Department of Medical Biotechnology and Laboratory Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China, 3 Laboratory of Nanomaterials, Chang Gung University, Taoyuan, Taiwan, Republic of China, 4 Research Center of Bacterial Pathogenesis, Chang Gung University, Taoyuan, Taiwan, Republic of China, 5 Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, United States of America, 6 Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York, United States of America, 7 Biochemical Engineering Research Center, Mingchi University of Technology, Taipei, Taiwan, Republic of China, 8 Cancer Research Center, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China, 9 Department of Respiratory Therapy, Fu Jen Catholic University, Taipei, Taiwan, Republic of China Abstract Agaricus blazei Murill (AbM) has been reported to possess immune activity against tumors and infections through stimulation of mononuclear phagocytes. Recently, AbM extract was shown to induce