原创力文档the armadillo repeat protein pf16 is essential for flagellar structure and function in plasmodium male gametes犰狳重复蛋白pf16是必不可少的疟原虫雄性配子的鞭毛结构和功能.pdfVIP
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the armadillo repeat protein pf16 is essential for flagellar structure and function in plasmodium male gametes犰狳重复蛋白pf16是必不可少的疟原虫雄性配子的鞭毛结构和功能
The Armadillo Repeat Protein PF16 Is Essential for
Flagellar Structure and Function in Plasmodium Male
Gametes
1,2. 2. 3 1 1
Ursula Straschil , Arthur M. Talman , David J. P. Ferguson , Karen A. Bunting , Zhengyao Xu ,
1 2 4 5 6
Elizabeth Bailes , Robert E. Sinden , Anthony A. Holder , Elizabeth F. Smith , Juliet C. Coates , Rita
Tewari1,2*
1 Institute of Genetics, School of Biology, University of Nottingham, Nottingham, United Kingdom, 2 Division of Cell and Molecular Biology, Imperial College London,
London, United Kingdom, 3 Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, 4 Division of
Parasitology, MRC National Institute for Medical Research, London, United Kingdom, 5 Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire,
United States of America, 6 School of Biosciences, University of Birmingham, Birmingham, United Kingdom
Abstract
Malaria, caused by the apicomplexan parasite Plasmodium, threatens 40% of the world’s population. Transmission between
vertebrate and insect hosts depends on the sexual stages of the life-cycle. The male gamete of Plasmodium parasite is the
only developmental stage that possesses a flagellum. Very little is known about the identity or function of proteins in the
parasite’s flagellar biology. Here, we characterise a Plasmodium PF16 homologue using reverse genetics in the mouse
malaria parasite Plasmodium berghei. PF16 is a conserved Armadillo-repeat protein that regulates flagellar str
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