原创力文档the association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis a cross-sectional study之间的关联微血管内皮功能和macrovascular类风湿性关节炎患者的横断面研究.pdfVIP
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the association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis a cross-sectional study之间的关联微血管内皮功能和macrovascular类风湿性关节炎患者的横断面研究
Sandoo et al. Arthritis Research Therapy 2011, 13:R99
/content/13/3/R99
RESEARCH ARTICLE Open Access
The association between microvascular and
macrovascular endothelial function in patients
with rheumatoid arthritis: a cross-sectional study
1,2* 2 1 1,3 1,2
Aamer Sandoo , Douglas Carroll , George S Metsios , George D Kitas and Jet JCS Veldhuijzen van Zanten
Abstract
Introduction: Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One
of the earliest manifestations of CVD is endothelial dysfunction (ED). ED can occur in both the microcirculation and
the macrocirculation, and these manifestations might be relatively independent of each other. Little is known
about the association between endothelial function in the microcirculation and the macrocirculation in RA. The
objectives of the present study were to examine the relationship between microvascular and macrovascular
endothelial function in patients with RA.
Methods: Ninety-nine RA patients (72 females, mean age (± SD) 56 ± 12 years), underwent assessments of
endothelial-dependent (acetylcholine) and endothelial-independent (sodium nitroprusside) microvascular
vasodilatory function (laser Doppler imaging with iontophoresis), as well as endothelial-dependent (flow-mediated
dilation) and endothelial-independent (glyceryl trinitrate-mediated dilation) macrovascular vasodilatory function.
Vasodilatory function was calculated as the percentage increase after each stimulus was applied relative to baseline
values.
Results: Pearson correlations showed that microvascular endothelial-dependent function was not associated with
macrovascular endothelial-dependent function (r (90 p
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