原创力文档the association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people a cross-sectional study瘦素之间的关系、白细胞介素- 6和髋关节骨关节炎影像学在老年人一个横断面研究.pdfVIP
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the association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people a cross-sectional study瘦素之间的关系、白细胞介素- 6和髋关节骨关节炎影像学在老年人一个横断面研究
Stannus et al. Arthritis Research Therapy 2010, 12:R95
/content/12/3/R95
R E S E A R C H A R T I C L E Open Access
Research article
The association between leptin, interleukin-6, and
hip radiographic osteoarthritis in older people: a
cross-sectional study
1 1 1 2 1 1,2
Oliver P Stannus , Graeme Jones , Stephen J Quinn , Flavia M Cicuttini , Dawn Dore and Changhai Ding*
Abstract
Introduction: The associations between leptin, interleukin (IL)-6, and hip radiographic osteoarthritis (OA) have not
been reported, and their roles in obesity-related hip OA are unclear. The aim of this study was to describe the
associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults.
Methods: A cross-sectional sample of 193 randomly selected subjects (mean age, 63 years; range, 52 to 78 years; 48%
female subjects) were studied. Hip ROA, including joint-space narrowing (JSN) and osteophytes, was determined by
anteroposterior radiograph. Serum levels of leptin and interleukin (IL)-6 were measured with radioimmunoassay. Fat
mass was measured with dual-energy x-ray absorptiometry (DXA). Body mass index (BMI) and waist-to-hip ratio (WHR)
were calculated.
Results: In multivariable analysis, hip JSN was associated with serum levels of leptin in the whole sample (β = 0.046 per
μg/L, P = 0.024 for superior; β = 0.068 per μg/L, P = 0.004 for axial compartment) and IL-6 only in females (β = 0.241 per
pg/ml, P = 0.002 for superior; β = 0.239 per pg/ml, P = 0.001 for axial compartment). The positive associations between
body-composition measures (BMI, WHR, percentage total fat mass, and percentage trunk fat mass) and hip JSN in
women became nonsignificant after adjustment for leptin but not for IL
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