原创力文档the crash trial the first large-scale, randomised, controlled trial in head injury碰撞试验第一次大规模、随机对照试验在头部受伤.pdfVIP
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the crash trial the first large-scale, randomised, controlled trial in head injury碰撞试验第一次大规模、随机对照试验在头部受伤
Critical Care December 2001 Vol 5 No 6 Roberts
Commentary
The CRASH trial: the first large-scale, randomised, controlled
trial in head injury
Ian Roberts
CRASH Trial Management Group, CRASH Co-ordinating Centre, London School of Hygiene Tropical Medicine, London, UK
Correspondence: Ian Roberts, Ian.Roberts@lshtm.ac.uk
Published online: 1 October 2001
Critical Care 2001, 5:292-293
© 2001 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X)
Abstract
The global epidemic of head injuries is just beginning. Many are caused by road traffic crashes. It is
estimated that, by 2020, road traffic crashes will have moved from its present position of ninth to third
in the world disease burden ranking, as measured in disability adjusted life years. In developing
countries, it will have moved to second. The Corticosteroid Randomisation After Significant Head Injury
(CRASH) trial is a large-scale, randomised, controlled trial, among adults with head injury and impaired
consciousness, of the effects of a short-term infusion of corticosteroids on death and on neurological
disability. Following a successful pilot phase, which included over 1000 randomised participants, the
main phase of the trial is now underway. Over the next 5 years, the trial aims to recruit a total of 20,000
patients. Such large numbers will only be possible if hundreds of doctors and nurses can collaborate in
emergency departments all over the world. The trial is currently recruiting, and new collaborators are
welcome to join the trial (see www.crash.lshtm.ac.uk).
Keywords brain injury, emergency medicine, head injury, injury, neurotrauma, trauma
The global epidemic of head injuries is just beginning. At
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