原创力文档the diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to heppar-1的诊断价值arginase-1疣状从转移癌分化肝细胞癌和胆管癌与heppar-1相比.pdfVIP
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the diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to heppar-1的诊断价值arginase-1疣状从转移癌分化肝细胞癌和胆管癌与heppar-1相比
Radwan and Ahmed Diagnostic Pathology 2012, 7:149
/content/7/1/149
RESEARCH Open Access
The diagnostic value of arginase-1
immunostaining in differentiating hepatocellular
carcinoma from metastatic carcinoma and
cholangiocarcinoma as compared to HepPar-1
*
Nehal A Radwan and Naglaa S Ahmed
Abstract
Background: The ability to distinguish hepatocellular carcinoma (HCC) from metastatic carcinoma (MC) involving
the liver and cholangiocarcinoma (CC) by immunohistochemistry has been limited by the lack of a reliable positive
marker for hepatocellular differentiation. Arginase-1 is a marker for HCC recently described in some literature.
Aim: To examine the immunohistochemical staining of arginase-1 in cases of HCC, MC involving the liver and CC
as compared to hepatocyte paraffin antigen -1 (HepPar-1) in an attempt to further define the diagnostic utility of
arginase-1 in differentiating these tumors.
Materials and methods: A comparative immunohistochemical study of arginase-1 and HepPar-1expression was
performed in 50 HCC cases, 38 cases of MC to the liver from varying sites, 12 cases of CC and 10 specimens of
normal liver tissues. The predictive capacity of arginase-1 and HepPar-1 staining was determined using sensitivity,
specificity, positive predictive value, and negative predictive value calculations.
Results: All normal liver tissues (no=10), non- neoplastic cirrhotic liver tissues adjacent to HCC (no=42) as well as
those adjacent to MC (no= 9) showed diffuse and strong immunostaining for both arginase-1 and HepPar-1.
Arginase-1 demonstrated positive immunoreactivity in 42 of 50 (84%) cases of HCC compared with 35 of 50 (70%)
for HepPar-1. Only one of 38 (2.6%) cases of MC and one of 12 (8.3%) cases of CC showed positive
immunoreactivity for arginase-1. In contrast, HepPar-1 imm
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