the differential effect of nat2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotypenat2的微分效应在表型变异等位基因允许改进推理和标识一个非常缓慢的乙酰化作用的基因型.pdfVIP

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2017-11-02 发布于上海
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the differential effect of nat2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotypenat2的微分效应在表型变异等位基因允许改进推理和标识一个非常缓慢的乙酰化作用的基因型.pdf

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the differential effect of nat2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotypenat2的微分效应在表型变异等位基因允许改进推理和标识一个非常缓慢的乙酰化作用的基因型

The Differential Effect of NAT2 Variant Alleles Permits Refinement in Phenotype Inference and Identifies a Very Slow Acetylation Genotype 1 ´ 1 2 3 4 ´ Jhon D. Ruiz , Carmen Martınez , Kristin Anderson , Myron Gross , Nicholas P. Lang , Elena Garcıa- ´ 5 ´ ´ 1 Martın , Jose A. G. Agundez * ´ 1 Department of Pharmacology, Medical School, University of Extremadura, Badajoz Caceres, Spain, 2 Division of Epidemiology Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America, 3 Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America, 4 Department of Surgery, University of Arkansas Medical Sciences, Little Rock, Arkansas, United States of ´ America, 5 Department of Biochemistry Molecular Biology, School of Biological Sciences, University of Extremadura, Caceres, Spain Abstract Indirect evidences suggest that acetylation phenotype categories are heterogeneous and that subcategories, related to specific NAT2 variant alleles might exist. We analyzed the in vivo acetylation phenotype and genotype in 504 north- American subjects of Caucasian origin. The analyses of the SNPs rs1801280 and rs1799930 allowed the discrimination of five categories with different acetylation status within the study population. These categories are related to the distinct effect of NAT2 alle