原创力文档the ccctc-binding factor (ctcf) of drosophila contributes to the regulation of the ribosomal dna and nucleolar stabilityccctc-binding因素(ctcf)果蝇导致核糖体dna的规定和核仁的稳定.pdfVIP
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the ccctc-binding factor (ctcf) of drosophila contributes to the regulation of the ribosomal dna and nucleolar stabilityccctc-binding因素(ctcf)果蝇导致核糖体dna的规定和核仁的稳定
The CCCTC-Binding Factor (CTCF) of Drosophila
Contributes to the Regulation of the Ribosomal DNA and
Nucleolar Stability
1 2
Paola A. Guerrero , Keith A. Maggert *
1 Department of Biochemistry/Biophysics, Texas AM University, College Station, Texas, United States of America, 2 Department of Biology, Texas AM University, College
Station, Texas, United States of America
Abstract
In the repeat array of ribosomal DNA (rDNA), only about half of the genes are actively transcribed while the others are
silenced. In arthropods, transposable elements interrupt a subset of genes, often inactivating transcription of those genes.
Little is known about the establishment or separation of juxtaposed active and inactive chromatin domains, or preferential
inactivation of transposable element interrupted genes, despite identity in promoter sequences. CTCF is a sequence-specific
DNA binding protein which is thought to act as a transcriptional repressor, block enhancer-promoter communication, and
delimit juxtaposed domains of active and inactive chromatin; one or more of these activities might contribute to the
regulation of this repeated gene cluster. In support of this hypothesis, we show that the Drosophila nucleolus contains
CTCF, which is bound to transposable element sequences within the rDNA. Reduction in CTCF gene activity results in
nucleolar fragmentation and reduced rDNA silencing, as does disruption of poly-ADP-ribosylation thought to be necessary
for CTCF nucleolar localization. Our data establish a role for CTCF as a component necessary for proper control of
transposable element-laden rDNA transcription and nucleolar stability.
Citation: Guerrero PA, Maggert KA (2011) The CCCTC-Binding Factor (CTCF) of Drosophil
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