原创力文档tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase ctezosentan-induced衰减endotoxemic羊与肺损伤的蛋白激酶c的激活.pdfVIP
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tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase ctezosentan-induced衰减endotoxemic羊与肺损伤的蛋白激酶c的激活
Available online /content/9/3/R211
Vol 9 No 3 Open Access
Research
Tezosentan-induced attenuation of lung injury in endotoxemic
sheep is associated with reduced activation of protein kinase C
1 1 2 3 4
Vladimir Kuklin , Mikhail Kirov , Mikhail Sovershaev , Thomas Andreasen , Ole C Ingebretsen ,
Kirsti Ytrehus5 and Lars Bjertnaes6
1Research Fellow, Department of Anesthesiology, Faculty of Medicine, University of Tromsø, Norway
2Research Fellow, Department of Physiology, Faculty of Medicine, University of Tromsø, Norway
3Departmental engineer, Department of Physiology, Faculty of Medicine, University of Tromsø, Norway
4Professor, Department of Clinical Chemistry, University Hospital of Tromsø, Norway
5Professor, Department of Physiology, Faculty of Medicine, University of Tromsø, Norway
6Professor, Chairman of the Department of Anesthesiology, Faculty of Medicine, University of Tromsø, Norway
Corresponding author: Lars Bjertnaes, lars.bjertnaes@unn.no
Received: 24 Nov 2004 Revisions requested: 9 Jan 2005 Revisions received: 27 Jan 2005 Accepted: 16 Feb 2005 Published: 14 Mar 2005
Critical Care 2005, 9:R211-R217 (DOI 10.1186/cc3497)
This article is online at: /content/9/3/R211
© 2005 Kuklin et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/
2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Studies in vitro reveal that endothelin-1 (ET-1) interleukin-8 (IL-
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