原创力文档the differential formation of the linc-mediated perinuclear actin cap in pluripotent and somatic cells的微分形成linc-mediated细胞核周围的肌动蛋白帽多能和体细胞.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
the differential formation of the linc-mediated perinuclear actin cap in pluripotent and somatic cells的微分形成linc-mediated细胞核周围的肌动蛋白帽多能和体细胞
The Differential Formation of the LINC-Mediated
Perinuclear Actin Cap in Pluripotent and Somatic Cells
1,2 1,2,3 1,2 3 4
Shyam B. Khatau , Sravanti Kusuma , Donny Hanjaya-Putra , Prashant Mali , Linzhao Cheng ,
Jerry S. H. Lee1,5, Sharon Gerecht1,2, Denis Wirtz1,2*
1 Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America, 2 Johns Hopkins Physical Sciences
– Oncology Center and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, Maryland, United States of America, 3 Department of Biomedical
Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America, 4 Institute for Cell Engineering and Department of Medicine, Johns Hopkins
School of Medicine, Baltimore, Maryland, United States of America, 5 Center for Strategic Scientific Initiatives, Office of the Director, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland, United States of America
Abstract
The actin filament cytoskeleton mediates cell motility and adhesion in somatic cells. However, whether the function and
organization of the actin network are fundamentally different in pluripotent stem cells is unknown. Here we show that while
conventional actin stress fibers at the basal surface of cells are present before and after onset of differentiation of mouse
(mESCs) and human embryonic stem cells (hESCs), actin stress fibers of the actin cap, which wrap around the nucleus, are
completely absent from undifferentiated mESCs and hESCs and their formation strongly correlates with differentiation.
Similarly, the perinuclear actin cap is absent from human induced pluripotent stem cells (hiPSCs), while it
您可能关注的文档
- the cerebellum link to neuroticism a volumetric mri association study in healthy volunteers小脑链接神经质体积mri协会的一项研究在健康志愿者.pdf
- the cercal organ may provide singing tettigoniids a backup sensory system for the detection of eavesdropping batscercal机关可以提供唱歌tettigoniids备份感觉系统检测窃听的蝙蝠.pdf
- the challenge of designing a post-critical illness rehabilitation intervention设计的挑战后批判疾病康复干预.pdf
- the challenge of synthesizing oligomers for molecular wires合成的寡聚物分子导线的挑战.pdf
- the cf-circ study a french collaborative study to assess the accuracy of cystic fibrosis diagnosis in neonatal screeningcf-circ研究法国协作研究评估囊性纤维化诊断新生儿筛查的准确性.pdf
- the challenge to revert unsustainable trends uneven development and water degradation in the rio de janeiro metropolitan area挑战回复不可持续的发展不平衡和水资源退化趋势在里约热内卢市区.pdf
- the change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes内皮祖细胞的变化和影响猪与多器官功能障碍综合征.pdf
- the cerebrospinal fluid proteome in hiv infection change associated with disease severity艾滋病毒感染的脑脊液蛋白质组变化与疾病严重程度有关.pdf
- the challenge of managing marine biodiversity a practical toolkit for a cartographic, territorial approach管理海洋生物多样性的挑战一个实用的制图工具箱,领土的方法.pdf
- the changes of nutrition labeling of packaged food in hangzhou in china during 2008～2010包装食品的营养标签的变化在2008 ~ 2010年在中国杭州.pdf
- the differences in brain activity between narrow band noise and pure tone tinnitus大脑活动之间的差异窄带噪声和纯质的音调耳鸣.pdf
- the discodermia calyx toxin calyculin a enhances cyclin d1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cellsdiscodermia花萼毒素calyculin有提高细胞周期蛋白d1磷酸化和退化,人类乳腺癌细胞细胞周期进程和逮捕.pdf
- the diploid genome sequence of an individual human人类个体的二倍体基因组序列.pdf
- the digital fish library using mri to digitize, database, and document the morphological diversity of fish数字鱼库使用mri数字化、数据库和文档的形态多样性的鱼.pdf
- the discovery of small-molecule mimicking peptides through phage display小分子的发现模仿通过噬菌体展示肽.pdf
- the differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation肿瘤坏死因子的差贡献在慢性炎症热力和机械痛觉过敏.pdf
- the differential proliferative ability of satellite cells in lantang and landrace pigs卫星细胞的增殖能力差lantang猪和长白猪.pdf
- the discovery of putative urine markers for the specific detection of prostate tumor by integrative mining of public genomic profiles假定的尿液标志物的发现的具体检测前列腺肿瘤的综合矿业公共基因组资料.pdf
- the discovery, positioning and verification of a set of transcription-associated motifs in vertebrates发现、定位和验证脊椎动物的一组transcription-associated图案.pdf
- the dissemination of st80-sccmec-iv community-associated methicillin resistant staphylococcus aureus clone in kuwait hospitals的传播st80-sccmec-iv community-associated耐甲氧西林金黄色葡萄球菌克隆在科威特医院.pdf
文档评论（0）