原创力文档the cell adhesion molecule “car” and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution细胞粘附分子u201c车u201d和唾液酸对人类腺病毒体内biodistribution红细胞的影响.pdfVIP
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the cell adhesion molecule “car” and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution细胞粘附分子u201c车u201d和唾液酸对人类腺病毒体内biodistribution红细胞的影响
The Cell Adhesion Molecule ‘‘CAR’’ and Sialic Acid on
Human Erythrocytes Influence Adenovirus In Vivo
Biodistribution
Elena Seiradake1., Daniel Henaff2,3., Harald Wodrich2,3, Olivier Billet2,3, Matthieu Perreau2,3, Claire
2,3 2,3 4 5 2,3 2,3
Hippert , Franck Mennechet , Guy Schoehn , Hugues Lortat-Jacob , Hanna Dreja , Sandy Ibanes ,
2,3 6 6 1,4 2,3
Vasiliki Kalatzis , Jennifer P. Wang , Robert W. Finberg , Stephen Cusack *, Eric J. Kremer *
´ ´ ´
1 European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France, 2 Institut de Genetique Moleculaire de Montpellier, CNRS 5535, Montpellier, France,
´
3 Universities Montpellier I II, Montpellier, France, 4 Unit of Virus-Host Cell Interactions, UMR 5233, UJF-EMBL-CNRS, Grenoble, France, 5 Institut de Biologie Structurale,
UMR 5075 CEA-CNRS-UJF, Grenoble, France, 6 Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Abstract
Although it has been known for 50 years that adenoviruses (Ads) interact with erythrocytes ex vivo, the molecular and
structural basis for this interaction, which has been serendipitously exploited for diagnostic tests, is unknown. In this study,
we characterized the interaction between erythrocytes and unrelated Ad serotypes, human 5 (HAd5) and 37 (HAd37), and
canine 2 (CAV-2). While these serotypes agglutinate huma
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