the dna transposon minos as a tool for transgenesis and functional genomic analysis in vertebrates and invertebratesdna转座子minos作为转基因技术和功能基因组分析工具在脊椎动物和无脊椎动物.pdfVIP

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the dna transposon minos as a tool for transgenesis and functional genomic analysis in vertebrates and invertebratesdna转座子minos作为转基因技术和功能基因组分析工具在脊椎动物和无脊椎动物.pdf

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the dna transposon minos as a tool for transgenesis and functional genomic analysis in vertebrates and invertebratesdna转座子minos作为转基因技术和功能基因组分析工具在脊椎动物和无脊椎动物

Review The DNA transposon Minos as a tool for transgenesis and functional genomic analysis in vertebrates and invertebrates † ‡ Anastasios Pavlopoulos* , Stefan Oehler*, Maria G Kapetanaki* and Charalambos Savakis*§ *Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Vassilika Vouton, PO Box 1385, Heraklion 71110, Crete, Greece. †Present address: Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK. ‡Present address: Department of Molecular Genetics and Biochemistry, School of Medicine, and Cancer Institute, University of Pittsburgh, Hillman Cancer Center, Centre Avenue, Pittsburgh, Philadelphia 15213, USA. §Medical School, University of Crete, Voutes, PO Box 2208, Heraklion 71003, Crete, Greece. Correspondence: Charalambos Savakis. E-mail: savakis@imbb.forth.gr Published: 31 October 2007 Genome Biology 2007, 8(Suppl 1):S2 (doi:10.1186/gb-2007-8-S1-S2) The electronic version of this article is the complete one and can be found online at /2007/8/S1/S2 © 2007 BioMed Central Ltd Abstract Transposons are powerful tools for conducting genetic manipulation and functional studies in organisms that are of scientific, economic, or medical interest. Minos, a member of the Tc1/mariner family of DNA transposons, exhibits a low insertional bias and transposes with high frequency in vertebrates and invertebrates. Its use as a tool for transgenesis and genome analysis of rather different animal species is described. Introduction homology with mobile elements of the Tc1/mariner super- Transposons employ intricate m