the genetic association of variants in cd6, tnfrsf1a and irf8 to multiple sclerosis a multicenter case-control study遗传变异协会cd6,tnfrsf1a irf8多发性硬化多中心病例对照研究.pdfVIP

The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study The International Multiple Sclerosis Genetics Consortium* Abstract Background: In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: r (CD6), rs1800693 (TNFRSF1A) and r(61.5 kb from IRF8). To refine our understanding of these associations we sought to replicate these findings in a large more extensive independent sample set of 11 populations of European origin. Principal Findings: We calculated individual and combined associations using a meta-analysis method by Kazeem and Farral (2005). We confirmed the association of rs1800693 in TNFRSF1A (p 4.19 61027, OR 1.12, 7,665 cases, 8,051 controls) and rnear IRF8 (p 5.35 610210, OR 0.84, 6,895 cases, 7,580 controls and 596 case-parent trios) The SNP rin CD6 also showed nominally significant evidence for association (p 2.19 61025, OR 1.11, 8,047 cases, 9,174 controls, 604 case-parent trios). Conclusions: Variants in TNFRSF1A and in the vicinity of IRF8 were confirmed to be associated in these independent cohorts, which supports the role of these loci in etiology of multiple sclerosis. The variant in CD6 reached genome-wide significance after combining the data with the original meta-analysis. Fine mapping is required to identify the predisposing variants in the loci and future functional studies will refine their molecular role in MS pathogenesis. Citation: The International Multiple Sclerosis Genetics Consortium (2011) The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study. PLoS ONE 6(4): e18813. doi:10.1371/journal.pone.0018