the genotype of early-transmitting hiv gp120s promotes α4β7 –reactivity, revealing α4β7+cd4+ t cells as key targets in mucosal transmissionearly-transmitting艾滋病毒的基因型gp120促进α4β7反应,揭示α4β7 + cd4 + t细胞在粘膜传播为主要目标.pdfVIP

The Genotype of Early-Transmitting HIV gp120s Promotes a b –Reactivity, Revealing a b +/CD4+ T cells 4 7 4 7 As Key Targets in Mucosal Transmission 1,2. 1. 1 1 1 Fatima Nawaz , Claudia Cicala , Donald Van Ryk , Katharine E. Block , Katija Jelicic , Jonathan P. 1 1 1 1 1 McNally , Olajumoke Ogundare , Massimiliano Pascuccio , Nikita Patel , Danlan Wei , Anthony S. 1 1 Fauci , James Arthos * 1 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 2 New York University School of Medicine Sackler Institute of Graduate Biomedical Sciences, New York, New York, United States of America Abstract Mucosal transmission of HIV is inefficient. The virus must breach physical barriers before it infects mucosal CD4+ T cells. Low- level viral replication occurs initially in mucosal CD4+ T cells, but within days high-level replication occurs in Peyer’s patches, the gut lamina propria and mesenteric lymph nodes. Understanding the early events in HIV transmission may provide valuable information relevant to the development of an HIV vaccine. The viral quasispecies in a donor contracts through a genetic bottleneck in the recipient, such that, in low-risk settings, infection is frequently established by a single founder virus. Early-transmitting viruses in subtypes A and C mucosal transmission tend to encode gp120s with reduced numbers of N-linked g