the hepatitis c virus nonstructural protein 2 (ns2) an up-and-coming antiviral drug target丙型肝炎病毒非结构蛋白2(ns2)的抗病毒药物的目标.pdfVIP

Viruses 2010, 2, 1635-1646; doi:10.3390/v2081635 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review The Hepatitis C Virus Nonstructural Protein 2 (NS2): An Up-and-Coming Antiviral Drug Target Ivo C. Lorenz † Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA † Present address: International AIDS Vaccine Initiative (IAVI), AIDS Vaccine Design Development Laboratory, Brooklyn Army Terminal, Building A Suite 8J, 140 58th Street, Brooklyn, NY 11220, USA; E-Mail: ILorenz@; Tel.: +1-646-381-8092; Fax: +1-718-765-1870. Received: 30 June 2010; in revised form: 3 August 2010 / Accepted: 4 August 2010 / Published: 6 August 2010 Abstract: Infection with Hepatitis C Virus (HCV) continues to be a major global health problem. To overcome the limitations of current therapies using interferon- in combination with ribavirin, there is a need to develop drugs that specifically block viral proteins. Highly efficient protease and polymerase inhibitors are currently undergoing clinical testing and will become available in the next few years. However, with resistance mutations emerging quickly, additional enzymatic activities or functions of HCV have to be targeted by novel compounds. One candidate molecule is the nonstructural protein 2 (NS2), which contains a proteolytic activity that is essential for viral RNA replication. In addition, NS2 is crucial for the assembly of progeny virions and modula