原创力文档the hepatitis c virus glycan shield and evasion of the humoral immune response丙型肝炎病毒多糖盾牌和逃税的体液免疫反应.pdfVIP
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the hepatitis c virus glycan shield and evasion of the humoral immune response丙型肝炎病毒多糖盾牌和逃税的体液免疫反应
Viruses 2011, 3, 1909-1932; doi:10.3390/v3101909
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
The Hepatitis C Virus Glycan Shield and Evasion of the
Humoral Immune Response
François Helle 1,*, Gilles Duverlie 1,2 and Jean Dubuisson 3
1 Laboratory of Virology, EA4294, Jules Verne University of Picardie, Amiens 80000, France;
E-Mail: gilles.duverlie@u-picardie.fr
2 Virology Department, Amiens University Hospital Center, South Hospital, Amiens 80000, France
3 Inserm U1019, CNRS UMR8204, Center for Infection and Immunity of Lille (CIIL),
Institut Pasteur de Lille, Université Lille Nord de France, Lille 59021, France;
E-Mail: jean.dubuisson@ibl.fr
* Author to whom correspondence should be addressed; E-Mail: francois.helle@u-picardie.fr;
Tel.: +33-322-827-925; Fax: +33-322-827-928.
Received: 27 July 2011; in revised form: 28 September 2011 / Accepted: 1 October 2011 /
Published: 14 October 2011
Abstract: Despite the induction of effective immune responses, 80% of hepatitis C virus
(HCV)-infected individuals progress from acute to chronic hepatitis. In contrast to the
cellular immune response, the role of the humoral immune response in HCV clearance is
still subject to debate. Indeed, HCV escapes neutralizing antibodies in chronically infected
patients and reinfection has been described in human and chimpanzee. Studies of
antibody-mediated HCV neutralization have long been hampered by the lack of
cell-culture-derived virus and the absence
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