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the human antibody response to dengue virus infection登革病毒感染的人类抗体反应
Viruses 2011, 3, 2374-2395; doi:10.3390/v3122374
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
The Human Antibody Response to Dengue Virus Infection
Wahala M. P. B. Wahala and Aravinda M. de Silva *
Department of Microbiology and Immunology, School of Medicine, University of North Carolina,
Chapel Hill, NC 27599, USA; E-Mails: wahala@
* Author to whom correspondence should be addressed; E-Mail: desilva@;
Tel.: +1-919-843-9964; Fax: +1-919-962-8103.
Received: 11 October 2011; in revised form: 12 November 2011 / Accepted: 15 November 2011 /
Published: 25 November 2011
Abstract: Dengue viruses (DENV) are the causative agents of dengue fever (DF) and
dengue hemorrhagic fever (DHF). Here we review the current state of knowledge about the
human antibody response to dengue and identify important knowledge gaps. A large body
of work has demonstrated that antibodies can neutralize or enhance DENV infection.
Investigators have mainly used mouse monoclonal antibodies (MAbs) to study interactions
between DENV and antibodies. These studies indicate that antibody neutralization of
DENVs is a “multi-hit” phenomenon that requires the binding of multiple antibodies to
neutralize a virion. The most potently neutralizing mouse MAbs bind to surface exposed
epitopes on domain III of the dengue envelope (E) protein. One challenge facing the
dengue field now is to extend these
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