原创力文档the human anti-il-1β monoclonal antibody acz885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis人类anti-il-1β单克隆抗体acz885是有效的在关节炎症小鼠模型和概念验证研究类风湿性关节炎患者.pdfVIP
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the human anti-il-1β monoclonal antibody acz885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis人类anti-il-1β单克隆抗体acz885是有效的在关节炎症小鼠模型和概念验证研究类风湿性关节炎患者
Available online /content/10/3/R67
Vol 10 No 3 Open Access
Research article
The human anti-IL-1β monoclonal antibody ACZ885 is effective in
joint inflammation models in mice and in a proof-of-concept study
in patients with rheumatoid arthritis
1 2 3 3 4
Rieke Alten , Hermann Gram , Leo A Joosten , Wim B van den Berg , Joachim Sieper ,
5 6 7 8 8
Siegfrid Wassenberg , Gerd Burmester , Piet van Riel , Maria Diaz-Lorente , Gerardus JM Bruin ,
8 8 8 8 8
Thasia G Woodworth , Christiane Rordorf , Yannik Batard , Andrew M Wright and Thomas Jung
1Department of Internal Medicine II, Rheumatology, Schlosspark-Klinik Teaching Hospital Charité University Medicine Berlin, Heubnerweg, D-14059
Berlin, Germany
2Novartis Institutes of Biomedical Research, Basel, CH-4002 Basel, Switzerland
3Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands
4Department of Rheumatology, Klinikum Benjamin Franklin, Hindenburgdamm, D-12200 Berlin, Germany
5Department of Rheumatology, Evangelisches Fachkrankenhaus, Rosenstraße, D-40882 Ratingen, Germany
6Department of Rheumatology, Charité, Charitéplatz, D-10117 Berlin, Germany
7Department of Rheumatology, University Medical Center St Radboud, Nijmegen 6500 HB, The Netherlands
8Novartis Exploratory Development, Werk St. Johann, Forum 1, CH-4002 Basel, Switzerland
Corresponding author: Thomas Jung, thomas.jung@
Received: 2 Jan
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