the human metapneumovirus matrix protein stimulates the inflammatory immune response in vitro人类metapneumovirus基质蛋白在体外刺激炎症免疫反应.pdfVIP

The Human Metapneumovirus Matrix Protein Stimulates the Inflammatory Immune Response In Vitro 1,2 3 2 2 1 Audrey Bagnaud-Baule , Olivier Reynard , Magali Perret , Jean-Luc Berland , Mimoun Maache , 2,4 2 3 ´ ` 1,2 Christophe Peyrefitte , Guy Vernet , Viktor Volchkov , Glaucia Paranhos-Baccala * ´ ´ ´ ´ 1 bioMerieux, Emerging Pathogens Department, Institut Federatif de Recherche 128 BioSciences Lyon Gerland, Lyon, France, 2 Fondation Merieux, Laboratoire des ` Pathogenes Emergents, Lyon Gerland, Lyon, France, 3 INSERM U758 Biologie des Filovirus, IFR128 BioSciences Lyon Gerland, Lyon, France, 4 Institut de Recherche ´ ´ Biomedicale des Armees, Grenoble, France Abstract Each year, during winter months, human Metapneumovirus (hMPV) is associated with epidemics of bronchiolitis resulting in the hospitalization of many infants. Bronchiolitis is an acute illness of the lower respiratory tract with a consequent inflammation of the bronchioles. The rapid onset of inflammation suggests the innate immune response may have a role to play in the pathogenesis of this hMPV infection. Since, the matrix protein is one of the most abundant proteins in the Paramyxoviridae family virion, we hypothesized that the inflammatory modulation observed in hMPV infected patients may be partly associated