原创力文档the impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome阻塞性睡眠呼吸暂停的影响连续代谢和炎症标记物在代谢综合征患者.pdfVIP
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the impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome阻塞性睡眠呼吸暂停的影响连续代谢和炎症标记物在代谢综合征患者
The Impact of Obstructive Sleep Apnea on Metabolic and
Inflammatory Markers in Consecutive Patients with
Metabolic Syndrome
1,2 1 1 1 1
Luciano F. Drager *, Heno F. Lopes , Cristiane Maki-Nunes , Ivani C. Trombetta , Edgar Toschi-Dias ,
1 1 2 ˜ 1 1
Maria Janieire N. N. Alves , Raffael F. Fraga , Jonathan C. Jun , Carlos E. Negrao , Eduardo M. Krieger ,
Vsevolod Y. Polotsky2, Geraldo Lorenzi-Filho1
˜ ˜
1 Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil, 2 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of
Medicine, Baltimore, Maryland, United States of America
Abstract
Background: Obstructive Sleep Apnea (OSA) is tightly linked to some components of Metabolic Syndrome (MetS). However,
most of the evidence evaluated individual components of the MetS or patients with a diagnosis of OSA that were referred
for sleep studies due to sleep complaints. Therefore, it is not clear whether OSA exacerbates the metabolic abnormalities in
a representative sample of patients with MetS.
2
Methodology/Principal Findings: We studied 152 consecutive patients (age 48 69 years, body mass index 32.363.4 Kg/m )
newly diagnosed with MetS (Adult Treatment Panel III). All participants underwent standard polysomnography irrespective
of sleep complaints, and laboratory measurements (glucose, lipid profile, uric acid and C-reactive protein).
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