the imperative for controlled mechanical stresses in unraveling cellular mechanisms of mechanotransduction控制机械应力的命令式解开细胞转导机制.pdfVIP

BioMedical Engineering OnLine BioMed Central Research Open Access The imperative for controlled mechanical stresses in unraveling cellular mechanisms of mechanotransduction 1 2 2 Eric J Anderson , Thomas D Falls , Adam M Sorkin and Melissa L Knothe Tate*1,2 Address: 1Dept. of Mechanical Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA and 2Dept. of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA Email: Eric J Anderson - eric.anderson@; Thomas D Falls - thomas.falls@; Adam M Sorkin - sorkin@; Melissa L Knothe Tate* - knothetate@ * Corresponding author Published: 03 May 2006 Received: 24 November 2005 Accepted: 03 May 2006 BioMedical Engineering OnLine 2006, 5:27 doi:10.1186/1475-925X-5-27 This article is available from: /content/5/1/27 © 2006 Anderson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: In vitro mechanotransduction studies are designed to elucidate cell behavior in response to a well-defined mechanical signal that is imparted to cultured cells, e.g. through fluid flow. Typically, flow rates are calculated based on a parallel plate flow assumption, to achieve a targeted cellular she