原创力文档the importance of identity-by-state information for the accuracy of genomic selectionidentity-by-state信息的重要性基因组选择的准确性.pdfVIP
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the importance of identity-by-state information for the accuracy of genomic selectionidentity-by-state信息的重要性基因组选择的准确性
Luan et al. Genetics Selection Evolution 2012, 44:28 Ge n e t i c s
/content/44/1/28 Se l e c t i o n
Evolution
RESEARCH Open Access
The importance of identity-by-state information
for the accuracy of genomic selection
1* 1,2 1,3 4 4,5
Tu Luan , John A Woolliams , Jørgen degård , Marlies Dolezal , Sergio I Roman-Ponce ,
Alessandro Bagnato4 and Theo HE Meuwissen1
Abstract
Background: It is commonly assumed that prediction of genome-wide breeding values in genomic selection is
achieved by capitalizing on linkage disequilibrium between markers and QTL but also on genetic relationships.
Here, we investigated the reliability of predicting genome-wide breeding values based on population-wide linkage
disequilibrium information, based on identity-by-descent relationships within the known pedigree, and to what
extent linkage disequilibrium information improves predictions based on identity-by-descent genomic relationship
information.
Methods: The study was performed on milk, fat, and protein yield, using genotype data on 35 706 SNP and
deregressed proofs of 1086 Italian Brown Swiss bulls. Genome-wide breeding values were predicted using a
genomic identity-by-state relationship matrix and a genomic identity-by-descent relationship matrix (averaged over
all marker loci). The identity-by-descent matrix was calculated by linkage analysis using one to five generations of
pedigree data.
Results: We showed that genome
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