原创力文档ω-conotoxins gvia, mviia and cvid sar and clinical potentialω-conotoxins gvia mviia cvid sar和临床潜力.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
ω-conotoxins gvia, mviia and cvid sar and clinical potentialω-conotoxins gvia mviia cvid sar和临床潜力
Mar. Drugs 2006, 4, 193-214
Marine Drugs
ISSN 1660-3397
© 2006 by MDPI
/marinedrugs
Special Issue on “Marine Drugs and Ion Channels” Edited by Hugo Arias
Review
ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical
Potential
Christina I. Schroeder and Richard J. Lewis*
Institute for Molecular Bioscience, The University of Queensland, St Lucia, 4072, QLD, Australia
E-mail: t.schroeder@.au (for Christina I. Schroeder)
* To whom correspondence should be addressed. Tel: +61-7-3346 2984; Fax: +61-7-3346 2101.
E-mail: r.lewis@.au
Received: 16 February 2006 / Accepted: 28 February 2006 / Published: 6 April 2006
Abstract: Highly selective N-type voltage-gated calcium (Ca ) channel inhibitors from
V
cone snail venom (the ω-conotoxins) have emerged as a new class of therapeutics for the
treatment of chronic and neuropathic pain. Earlier in 2005, Prialt (Elan) or synthetic ω-
conotoxin MVIIA, was the first ω-conotoxin to be approved by Food and Drug
Administration for human use. This review compares the action of three ω-conotoxins,
GVIA, MVIIA and CVID, describing their structure-activity relationships and potential as
leads for the design of improved N-type therapeutics that are more useful in the treatment of
chronic pain.
Keywords: ω-conotoxin, Structure-Activity relationship, pain.
Abbreviations: FDA, Food and Drug Administration; AChR, nicotinic ac
您可能关注的文档
- the gentle art of gene arrangement the meaning of gene clusters温柔的艺术基因排列基因集群的意义.pdf
- the ghosts in the computer the role of agency and animacy attributions in “ghost controls”计算机中的鬼魂机构的作用,为了更好的归因在u201c鬼控制u201d.pdf
- the geography of diabetes in london, canada the need for local level policy for prevention and management糖尿病的地理位置在伦敦,加拿大需要地方政策预防和管理.pdf
- the ghrelin signalling system is involved in the consumption of sweets胃促生长素信号系统参与消费的糖果.pdf
- the giant cafeteria roenbergensis virus that infects a widespread marine phagocytic protist is a new member of the fourth domain of life巨人cafeteria roenbergensis病毒感染广泛的海洋吞噬原生生物是第四域的新成员的生活.pdf
- the genus caesalpinia l. (caesalpiniaceae) phytochemical and pharmacological characteristics属石莲子l .(苏木科)的植物化学成分和药理特性.pdf
- the germinal center kinase tnik is required for canonical nf-κb and jnk signaling in b-cells by the ebv oncoprotein lmp1 and the cd40 receptor规范所需的生发中心激酶tnik nf-κb ebv和物信号在b细胞的癌蛋白lmp1和cd40受体.pdf
- the genomics and proteomics of biofilm formation基因组学和蛋白质组学的生物膜的形成.pdf
- the geographical distribution of p-m hybrid dysgenesis in drosophila melanogaster大学出版社的地理分布混合在黑腹果蝇发育不全.pdf
- the global challenge of antimicrobial resistance insights from economic analysis抗菌素耐药性的全球挑战的见解从经济分析.pdf
文档评论（0）