原创力文档tyrosinase-expressing neuronal cell line as in vitro model of parkinson’s diseasetyrosinase-expressing神经细胞株帕金森病的体外模型.pdfVIP
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tyrosinase-expressing neuronal cell line as in vitro model of parkinson’s diseasetyrosinase-expressing神经细胞株帕金森病的体外模型
Int. J. Mol. Sci. 2010, 11, 1082-1089; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Tyrosinase-Expressing Neuronal Cell Line as in Vitro Model of
Parkinson’s Disease
Takafumi Hasegawa
Department of Neurology Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai,
Miyagi 980-8574, Japan; E-Mail: hasegawa@em.neurol.med.tohoku.ac.jp; Tel.: +81-22-717-7189;
Fax: +81-22-717-7189.
Received: 18 January 2010; / Accepted: 3 March 2010 / Published: 12 March 2010
Abstract: Oxidized metabolites of dopamine known as dopamine quinone derivatives are
thought to play a pivotal role in the degeneration of nigrostriatal dopaminergic neurons in
Parkinson’s disease. Although such quinone derivatives are usually produced via the
autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis
via the production of DOPA and subsequent molecules, can potentially accelerate the
induction of catecholamine quinone derivatives by its oxidase activity. We have developed
neuronal cell lines in which the expression of human tyrosinase was inducible.
Overexpression of tyrosinase resulted in increased intracellular dopamine content in
association with the formation of melanin pigments in neuronal somata, which eventually
causes apoptotic cell death. This cellular model will
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