原创力文档ubiquitin fold modifier 1 (ufm1) and its target ufbp1 protect pancreatic beta cells from er stress-induced apoptosis泛素褶皱修饰符1(ufm1)及其目标ufbp1保护胰腺β细胞er应激细胞凋亡.pdfVIP
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ubiquitin fold modifier 1 (ufm1) and its target ufbp1 protect pancreatic beta cells from er stress-induced apoptosis泛素褶皱修饰符1(ufm1)及其目标ufbp1保护胰腺β细胞er应激细胞凋亡
Ubiquitin Fold Modifier 1 (UFM1) and Its Target UFBP1
Protect Pancreatic Beta Cells from ER Stress-Induced
Apoptosis
1 . 2. 1 2,5 3
Katleen Lemaire * , Rodrigo F. Moura , Mikaela Granvik , Mariana Igoillo-Esteve , Hans E. Hohmeier ,
1 3 4 2,5 1
Nico Hendrickx , Christopher B. Newgard , Etienne Waelkens , Miriam Cnop , Frans Schuit *
´
1 Gene Expression Unit, Department Molecular Cell Biology, KatholiekeUniversiteit Leuven, Leuven, Belgium, 2 Laboratory of Experimental Medicine, Universite Libre de
Bruxelles, Brussels, Belgium, 3 Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine, Duke University
Medical Center, Durham, North Carolina, United States of America, 4 Prometa, Department Molecular Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium,
5 Division of Endocrinology, Erasmus Hospital, Brussels, Belgium
Abstract
UFM1 is a member of the ubiquitin like protein family. While the enzymatic cascade of UFM1 conjugation has been
elucidated in recent years, the biological function remains largely unknown. In this report we demonstrate that the recently
identified C20orf116 [1], which we name UFM1-binding protein 1 containing a PCI domain (UFBP1), andCDK5RAP3 interact
with UFM1. Components of the UFM1 conjugation pathway (UFM1, UFBP1, UFL1 and CDK5RAP3) are highly expr
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