原创力文档variation in lpa is associated with lp(a) levels in three populations from the third national health and nutrition examination surveylpa的变化与lp(a)水平在三个人口第三次全国健康和营养调查.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
variation in lpa is associated with lp(a) levels in three populations from the third national health and nutrition examination surveylpa的变化与lp(a)水平在三个人口第三次全国健康和营养调查
Variation in LPA Is Associated with Lp(a) Levels in Three
Populations from the Third National Health and
Nutrition Examination Survey
1,2 1 1 3 3
Logan Dumitrescu , Kimberly Glenn , Kristin Brown-Gentry , Cynthia Shephard , Michelle Wong ,
3 3 3 1,2
Mark J. Rieder , Joshua D. Smith , Deborah A. Nickerson , Dana C. Crawford *
1 Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America, 2 Department of Molecular Physiology and Biophysics,
Vanderbilt University, Nashville, Tennessee, United States of America, 3 Department of Genome Sciences, University of Washington, Seattle, Washington, United States of
America
Abstract
The distribution of lipoprotein(a) [Lp(a)] levels can differ dramatically across diverse racial/ethnic populations. The extent to
which genetic variation in LPA can explain these differences is not fully understood. To explore this, 19 LPA tagSNPs were
genotyped in 7,159 participants from the Third National Health and Nutrition Examination Survey (NHANES III). NHANES III is
a diverse population-based survey with DNA samples linked to hundreds of quantitative traits, including serum Lp(a). Tests
of association between LPA variants and transformed Lp(a) levels were performed across the three different NHANES
subpopulations (non-Hispanic whites, non-Hispanic blacks, and Mexican Americans). At a significance threshold of
p,0.0001, 15 of the 19 SNPs tested were strongly associated with Lp(a) levels in at least one subpopulation, six in at least
two subpo
您可能关注的文档
- unfaithful maintenance of methylation imprints due to loss of maternal nuclear dnmt1 during somatic cell nuclear transfer不忠的维护甲基化痕迹由于损失的孕产妇核dnmt1在体细胞核移植.pdf
- unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for nkt cells独特的糖和脂质之间的相互作用在决定细菌抗原的抗原效价nkt细胞.pdf
- univariate cubic l1 interpolating splines spline functional, window size and analysis-based algorithm单变量l1立方插值样条函数样条函数、窗口大小和分析算法.pdf
- univariate cubic l1 interpolating splines analytical results for linearity, convexity and oscillation on 5-pointwindows单变量l1立方插值样条函数为线性分析结果,凸性和5-pointwindows振荡.pdf
- uniform approximation is more appropriate for wilcoxon rank-sum test in gene set analysis统一近似更适合wilcoxon rank-sum基因集的测试分析.pdf
- unique cell adhesion and invasion properties of yersinia enterocolitica o3, the most frequent cause of human yersiniosis独特的细胞粘附和入侵的性质就要enterocolitica o3,人类yersiniosis的最常见原因.pdf
- unique properties of eukaryote-type actin and profilin horizontally transferred to cyanobacteria独特的eukaryote-type肌动蛋白的性质和profilin水平转移到蓝藻.pdf
- universal entropy of word ordering across linguistic families通用词排序熵跨语言的家庭.pdf
- universal features of post-transcriptional gene regulation are critical for plasmodium zygote development转录后基因调控的普遍特征为疟原虫受精卵发展至关重要.pdf
- unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids独特的细胞特定类型交界复合物在血管内皮的人类和大鼠肝血窦.pdf
- vapc toxins from mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate vapb antitoxinsvapc结核分枝杆菌的毒素核糖核酸酶不同抑制增长和由同源中和vapb抗毒素.pdf
- variation in hsp70 levels after cold shock signs of evolutionary responses to thermal selection among leptinotarsa decemlineata populations冷休克后hsp70水平变化的迹象进化反应热选择leptinotarsa decemlineata人群.pdf
- variation in seed dormancy quantitative trait loci in arabidopsis thaliana originating from one site在拟南芥种子休眠数量性状位点的变化来自一个网站.pdf
- variation in the analysis of positively selected sites using nonsynonymoussynonymous rate ratios an example using influenza virus积极变化的分析选择网站使用nonsynonymoussynonymous率比使用流感病毒的一个例子.pdf
- variation in the structure of bird nests between northern manitoba and southeastern ontario鸟的巢穴的结构变化之间的北部马尼托巴省和安大略省东南部.pdf
- variation in tropical reef symbiont metagenomes defined by secondary metabolism热带礁共生者基因组由次生代谢的变化.pdf
- variation in courtship ultrasounds of three ostrinia moths with different sex pheromones求爱的变化三个ostrinia飞蛾与不同的性信息素的超声波.pdf
- variation in stability of endogenous reference genes in fallopian tubes and endometrium from healthy and ectopic pregnant women内生稳定性的变化从健康和参考基因在输卵管和子宫内膜异位孕妇.pdf
- variation of neisseria gonorrhoeae lipooligosaccharide directs dendritic cell–induced t helper responses淋病奈瑟氏菌的变化lipooligosaccharide指导树突cell-induced辅助t响应.pdf
- variation of basal erod activities in ten passerine bird species – relationships with diet and migration status变异的基底erod活动十雀形目的鸟类u2014u2014与饮食和迁移状态的关系.pdf
文档评论（0）