原创力文档unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for nkt cells独特的糖和脂质之间的相互作用在决定细菌抗原的抗原效价nkt细胞.pdfVIP
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unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for nkt cells独特的糖和脂质之间的相互作用在决定细菌抗原的抗原效价nkt细胞
Unique Interplay between Sugar and Lipid in
Determining the Antigenic Potency of Bacterial Antigens
for NKT Cells
1. 1. 1 2,3 4 1 5
Enrico Girardi , Esther Dawen Yu , Yali Li , Norihito Tarumoto , Bo Pei , Jing Wang , Petr Illarionov ,
2 4 1
Yuki Kinjo , Mitchell Kronenberg , Dirk M. Zajonc *
1 Division of Cell Biology, La Jolla Institute for Allergy Immunology, La Jolla, California, United States of America, 2 Department of Chemotherapy and Mycoses, National
Institute of Infectious Diseases, Tokyo, Japan, 3 Department of Infectious Disease and Infection Control, Saitama Medical University, Saitama, Japan, 4 Division of
Developmental Immunology, La Jolla Institute for Allergy Immunology, La Jolla, California, United States of America, 5 School of Biosciences, University of Birmingham,
Edgbaston, Birmingham, United Kingdom
Abstract
Invariant natural killer T (iNKT) cells are an evolutionary conserved T cell population characterized by features of both the
innate and adaptive immune response. Studies have shown that iNKT cells are required for protective responses to Gram-
positive pathogens such as Streptococcus pneumoniae, and that these cells recognize bacterial diacylglycerol antigens
presented by CD1d, a non-classical antigen-presenting molecule. The combination of a lipid backbone containing an
unusual fatty acid, vaccenic acid, as well as a glucose sugar that is weaker or not stimulatory when linked to other lipids, is
required for iNKT cell stimulation by these antigens. Here we
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