原创力文档vasorelaxation, induced by dictyota pulchella (dictyotaceae), a brown alga, is mediated via inhibition of calcium influx in rats引起的血管舒张,dictyota pulchella(网地藻科),褐藻,通过抑制介导的钙在老鼠身上涌入.pdfVIP
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vasorelaxation, induced by dictyota pulchella (dictyotaceae), a brown alga, is mediated via inhibition of calcium influx in rats引起的血管舒张,dictyota pulchella(网地藻科),褐藻,通过抑制介导的钙在老鼠身上涌入
Mar. Drugs 2011, 9, 2075-2088; doi:10.3390/md9102075
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Article
Vasorelaxation, Induced by Dictyota pulchella (Dictyotaceae), a
Brown Alga, Is Mediated via Inhibition of Calcium Influx in Rats
Thyago M. Queiroz, Natália T. Machado, Fabíola F. Furtado, Abrahão A. Oliveira-Filho,
Maria C. Alustau, Camila S. Figueiredo, George E. C. Miranda, José M. Barbosa-Filho,
Valdir A. Braga * and Isac A. Medeiros
Biotechnology Center, Federal University of Paraiba, João Pessoa, PB 58.051-900, Brazil;
E-Mails: thyagoqueiroz@ (T.M.Q.); naty_tabosa@ (N.T.M.);
fabiola.fialho@ (F.F.F.); abrahao.farm@ (A.A.O.-F);
karminha@ (M.C.A); mila_farma@ (C.S.F.);
mirandag@dse.ufpb.br (G.E.C.M.); jbarbosa@ltf.ufpb.br (J.M.B.-F.); isac@ltf.ufpb.br (I.A.M.)
* Author to whom correspondence should be addressed; E-Mail: valdir@ltf.ufpb.br;
Tel.: +55-083-3216-7366; Fax: +55-083-3362-2259.
Received: 23 August 2011; in revised form: 13 October 2011 / Accepted: 17 October 2011 /
Published: 24 October 2011
Abstract: This study aimed to investigate the cardiovascular effects elicited by Dictyota
pulchella , a brown alga, using in vivo and in vitro approaches. In normotensive conscious
rats, CH Cl /MeOH Extract (CME, 5, 10, 20 and 40 mg/kg) from Dictyota pulchella
2 2
produced dose-dependent hypotension (−4 ± 1; −8 ± 2; −53 ± 8 and −63 ± 3 mmHg) and
bradycardia (−8 ± 6; −17 ± 11; −257 ± 36 and −285 ± 27 b.p.m.). In addition, CME and
Hexane/EtOAc Phase (HEP) (0.01–300 µg/mL
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