原创力文档vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis后代的血管功能障碍引起孕产妇膳食脂肪包括改变动脉多不饱和脂肪酸的生物合成.pdfVIP
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vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis后代的血管功能障碍引起孕产妇膳食脂肪包括改变动脉多不饱和脂肪酸的生物合成
Vascular Dysfunction Induced in Offspring by Maternal
Dietary Fat Involves Altered Arterial Polyunsaturated
Fatty Acid Biosynthesis
1. 1. 1 2 1
Christopher J. Kelsall , Samuel P. Hoile , Nicola A. Irvine , Mojgan Masoodi , Christopher Torrens ,
3 1 1 1 1
Karen A. Lillycrop , Philip C. Calder , Geraldine F. Clough , Mark A. Hanson , Graham C. Burdge *
1 Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Hampshire, United Kingdom, 2 MRC Human Nutrition Research,
Elsie Widdowson Laboratory, Cambridge, United Kingdom, 3 Faculty of Natural and Environmental Sciences, University of Southampton, Hampshire, United Kingdom
Abstract
Nutrition during development affects risk of future cardiovascular disease. Relatively little is known about whether the
amount and type of fat in the maternal diet affect vascular function in the offspring. To investigate this, pregnant and
lactating rats were fed either 7%(w/w) or 21%(w/w) fat enriched in either18:2n-6, trans fatty acids, saturated fatty acids, or
fish oil. Their offspring were fed 4%(w/w) soybean oil from weaning until day 77. Type and amount of maternal dietary fat
altered acetylcholine (ACh)-mediated vaso-relaxation in offspring aortae and mesenteric arteries, contingent on sex.
Amount, but not type, of maternal dietary fat altered phenylephrine (Pe)-induced vasoconstriction in these arteries.
Maternal 21% fat diet decreased 20:4n-6 concentration in offspring aortae. We
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