原创力文档vcpp97, down-regulated by microrna-129-5p, could regulate the progression of hepatocellular carcinomavcpp97,抑制微rna - 129 - 5 - p,可以调节肝细胞癌的进展.pdfVIP
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vcpp97, down-regulated by microrna-129-5p, could regulate the progression of hepatocellular carcinomavcpp97,抑制微rna - 129 - 5 - p,可以调节肝细胞癌的进展
VCP/p97, Down-Regulated by microRNA-129-5p, Could
Regulate the Progression of Hepatocellular Carcinoma
1. 2. 2 1 1 3 3
Yu Liu , Yan Hei , Qingming Shu , Jie Dong , Yaping Gao , Hanjiang Fu , Xiaofei Zheng ,
Guang Yang1*
1 Beijing Institute of Basic Medical Sciences, Beijing, China, 2 People’s Armed Police Corps General Hospital, Beijing, China, 3 Beijing Institute of Radiation Medicine,
Beijing, China
Abstract
Valosin containing protein (VCP)/p97 plays various important roles in cells. Moreover, elevated expression of VCP in
hepatocellular carcinoma (HCC) is correlated with increased incidence of recurrence. But the role of VCP in HCC progression
in vitro and in vivo is unclear. And there are few reports about the regulation mechanism on the expression of VCP in HCC. In
this study, it was identified that the level of VCP was frequently increased in human HCC tissues. In addition, down-
regulation of VCP with siRNAs could dramatically suppress the genesis and progression of tumor in vivo. It was found that
miR-129-5p directly inhibited the expression of VCP in several HCC cell lines. Meanwhile, the level of VCP in HCC tissues was
negatively associated with the level of miR-129-5p. Our further investigation showed that the enhanced expression of miR-
129-5p also suppressed tumor growth in vivo. Moreover, it was revealed that miR-129-5p could inhibit the degradation of
IkBa and increase the apoptosis and reduce the migration of HCC cells by suppressing the expression of VCP. Our results
revealed that the expression of VCP was directly regulated by miR-129-5p and this regulation played an important role in
the progression of HCC.
Citation: Liu Y, Hei Y, Shu Q, Dong J, Gao Y, et al. (2012) VC
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