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viral organization of human proteins病毒的人类蛋白质的组织
Viral Organization of Human Proteins
1 2 2
Stefan Wuchty *, Geoffrey Siwo , Michael T. Ferdig
1 National Center of Biotechnology Information, National Institutes of Health, Bethesda, Maryland, United States of America, 2 Eck Institute for Global Health, Department
of Biology, University of Notre Dame, Notre Dame, Indiana, United States of America
Abstract
Although maps of intracellular interactions are increasingly well characterized, little is known about large-scale maps of
host-pathogen protein interactions. The investigation of host-pathogen interactions can reveal features of pathogenesis
and provide a foundation for the development of drugs and disease prevention strategies. A compilation of experimentally
verified interactions between HIV-1 and human proteins and a set of HIV-dependency factors (HDF) allowed insights into
the topology and intricate interplay between viral and host proteins on a large scale. We found that targeted and HDF
proteins appear predominantly in rich-clubs, groups of human proteins that are strongly intertwined among each other.
These assemblies of proteins may serve as an infection gateway, allowing the virus to take control of the human host by
reaching protein pathways and diversified cellular functions in a pronounced and focused way. Particular transcription
factors and protein kinases facilitate indirect interactions between HDFs and viral proteins. Discerning the entanglement of
directly targeted and indirectly interacting proteins may uncover molecular and functional sites that can provide novel
perspectives on the progression of HIV infection and highlight new avenues to fight this virus.
Citation: Wuchty S, Siwo G, Ferdig MT (2010) Viral Organization of Human Proteins. PLoS ONE 5(8): e11796. doi:10.1371
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