vinegar-baked radix bupleuri regulates lipid disorders via a pathway dependent on peroxisome-proliferator-activated receptor- in high-fat-diet-induced obese rats英文论文.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 827278, 12 pages doi:10.1155/2012/827278 Research Article Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-α in High-Fat-Diet-Induced Obese Rats Thing-Fong Tzeng,1 Hung-Jen Lu,2 Shorong-Shii Liou,3 Chia Ju Chang,4 and I-Min Liu3 1 Department of Internal Medicine, Pao Chien Hospital, Pingtung City, Pingtung County 90065, Taiwan 2 Traditional Medicinal Center, Kaohsiung Veterans General Hospital, Kaohsiung City 81362, Taiwan 3 Department of Pharmacy Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Pingtung Shien 90701, Taiwan 4 School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan Correspondence should be addressed to I-Min Liu, iml@.tw Received 19 June 2011; Accepted 23 September 2011 Academic Editor: Vincenzo De Feo Copyright © 2012 Thing-Fong Tzeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of this study was to investigate the antiobesity and antihyperlipidemic effects of vinegar-baked Radix Bupleuri (VBRB) on high-fat diet- (HFD-) induced obese rats. After being fed HFD for two weeks, rats were dosed orally with VBRB or fenofibrate, once daily for further twelve weeks. VBRB (1.0 g kg−1 per day) produced effects similar to fenofibrate (100 mg kg−1) in reducing body weight (BW) gain, visceral fat-pad weights, plasma lipid levels, as well as hepatic TG and cholesterol content of HFD- fed rats.