use of temporary implantable biomaterials to reduce leg pain and back pain in patients with sciatica and lumbar disc herniation使用临时植入生物材料以减少腿部疼痛和背部疼痛患者的坐骨神经痛和腰椎间盘突出症.pdfVIP

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use of temporary implantable biomaterials to reduce leg pain and back pain in patients with sciatica and lumbar disc herniation使用临时植入生物材料以减少腿部疼痛和背部疼痛患者的坐骨神经痛和腰椎间盘突出症.pdf

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use of temporary implantable biomaterials to reduce leg pain and back pain in patients with sciatica and lumbar disc herniation使用临时植入生物材料以减少腿部疼痛和背部疼痛患者的坐骨神经痛和腰椎间盘突出症

Materials 2010, 3, 3331-3368; doi:10.3390/ma3053331 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review Use of Temporary Implantable Biomaterials to Reduce Leg Pain and Back Pain in Patients with Sciatica and Lumbar Disc Herniation Gere S. diZerega 1,*, Melissa M. Traylor 2, Lisa S. Alphonso 2 and Samuel J. Falcone 2 1 Keck School of Medicine at University of Southern California / 1321 N. Mission Road, Los Angeles, CA 90033, USA 2 FzioMed, Inc. / 231 Bonetti Drive, San Luis Obispo, CA 90033, USA; E-Mails: mtraylor@ (M.M.T.); lalphonso@ (L.S.A.); sfalcone@ (S.J.F.) * Author to whom correspondence should be addressed; E-Mail: dizerega@; Tel.: +1-323-226-4965; Fax: +1-323-222-7038. Received: 23 January 2010; in revised form: 13 May 2010 / Accepted: 17 May 2010 / Published: 19 May 2010 Abstract: The principle etiology of leg pain (sciatica) from lumbar disc herniation is mechanical compression of the nerve root. Sciatica is reduced by decompression of the herniated disc, i.e., removing mechanical compression of the nerve root. Decompression surgery typically reduces sciatica more than lumbar back pain (LBP). Decompression surgery reduces mechanical compression of the nerve root. However, decompression surgery does not directly reduce sensitization of the sensory nerves in the epidural space and disc. In addition, sensory nerves in the annulus fibrosus and epidural space are not