原创力文档use of rna interference by in utero electroporation to study cortical development the example of the doublecortin superfamily利用rna干扰在子宫内电穿孔研究皮质发展的例子doublecortin总科.pdfVIP
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use of rna interference by in utero electroporation to study cortical development the example of the doublecortin superfamily利用rna干扰在子宫内电穿孔研究皮质发展的例子doublecortin总科
Genes 2012, 3, 759-778; doi:10.3390/genes3040759
OPEN ACCESS
genes
ISSN 2073-4425
/journal/genes
Review
Use of RNA Interference by In Utero Electroporation to Study
Cortical Development: The Example of the
Doublecortin Superfamily
Orly Reiner *, Anna Gorelik and Raanan Greenman
Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel;
E-Mails: anna.gorelik@weizmann.ac.il (A.G.); raanan.greenman@weizmann.ac.il (R.G.)
* Author to whom correspondence should be addressed; E-Mail: orly.reiner@weizmann.ac.il;
Tel.: +972-8-934-2319; Fax: +972-8-934-4108.
Received: 27 September 2012; in revised form: 22 October 2012 / Accepted: 31 October 2012 /
Published: 21 November 2012
Abstract: The way we study cortical development has undergone a revolution in the last
few years following the ability to use shRNA in the developing brain of the rodent embryo.
The first gene to be knocked-down in the developing brain was doublecortin (Dcx). Here
we will review knockdown experiments in the developing brain and compare them with
knockout experiments, thus highlighting the advantages and disadvantages using the
different systems. Our review will focus on experiments relating to the doublecortin
superfamily of proteins.
Keywords: doublecortin; DCX; shRNA; in utero electroporation; neuronal migration
1. Introduction
The human cerebral cortex is the seat of cognition and as such, a focus of many intensive studies. In
humans, brain malfunctioning may be detected early in life
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