原创力文档type ii nkt cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistanceii型nkt细胞刺激食源性肥胖通过调解脂肪组织炎症、肝病和胰岛素抵抗.pdfVIP
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type ii nkt cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistanceii型nkt细胞刺激食源性肥胖通过调解脂肪组织炎症、肝病和胰岛素抵抗
Type II NKT Cells Stimulate Diet-Induced Obesity by
Mediating Adipose Tissue Inflammation, Steatohepatitis
and Insulin Resistance
1,2. 2,3. 2,4 2 5
Masashi Satoh , Yasuhiro Andoh , Christopher Stuart Clingan , Hisako Ogura , Satoshi Fujii , Koji
1 6 7 2,8 3
Eshima , Toshinori Nakayama , Masaru Taniguchi , Noriyuki Hirata , Naoki Ishimori , Hiroyuki
3 ´ 2 1,2
Tsutsui , Kazunori Onoe , Kazuya Iwabuchi *
1 Department of Immunology, Kitasato University School of Medicine, Sagamihar, Japan, 2 Division of Immunobiology, Research Section of Pathophysiology, Institute for
Genetic Medicine, Hokkaido University, Sapporo, Japan, 3 Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan,
4 Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 5 Department of Molecular and
Cellular Pathobiology and Therapeutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan, 6 Department of Immunology, Graduate
School of Medicine, Chiba University, Chiba, Japan, 7 RIKEN Research Center for Allergy and Immunology, Yokohama, Japan, 8 Division of Cancer Biology, Research
Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
Abstract
The progression of obesity is accompanied by a chronic inflammatory process that involves both innate and acquired
immunity. Natural killer T (NK
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