tyrosine kinase etkbmx is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy酪氨酸激酶etkbmx上调在膀胱癌和胆囊切除术患者的不良预后的预测.pdfVIP

Tyrosine Kinase ETK/BMX Is Up-Regulated in Bladder Cancer and Predicts Poor Prognosis in Patients with Cystectomy 1,4 1 1 1 1 2 5 Shengjie Guo , Feng Sun , Zhiyong Guo , Wei Li , Alan Alfano , Hegang Chen , Clara E. Magyar , Jiaoti 5 3 4 1 Huang , Toby C. Chai , Shaopeng Qiu *, Yun Qiu * 1 Department of Pharmacology and Experimental Therapeutics and The Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 2 Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 3 Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 4 Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 5 Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America Abstract Deregulation of the non-receptor tyrosine kinase ETK/BMX has been reported in several solid tumors. In this report, we demonstrated that ETK expression is progressively increased during bladder cancer progression. We found that down- regulation of ETK in bladder cancer cells attenuated STAT3 and AKT activity whereas exogenous overexpression of ETK had opposite effects, suggesting that deregulation of ETK may attribute to the elevated activity of STAT3 and AKT frequently detected in bladder cancer. The survival, migration and invasion of bladder cancer cells were significantly compromised when ETK expression was knocked down by a s