原创力文档ube4b a promising regulatory molecule in neuronal death and survivalube4b承诺监管分子在神经元死亡和生存.pdfVIP
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ube4b a promising regulatory molecule in neuronal death and survivalube4b承诺监管分子在神经元死亡和生存
Int. J. Mol. Sci. 2012, 13, 16865-16879; doi:10.3390/ijms131216865
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
UBE4B: A Promising Regulatory Molecule in Neuronal Death
and Survival
Rami Abou Zeinab, Hong Wu, Consolato Sergi and Roger Leng *
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2S2,
Canada; E-Mails: abouzein@ualberta.ca (R.A.Z.); hwu4@ualberta.ca (H.W.); sergi@ualberta.ca (C.S.)
* Author to whom correspondence should be addressed; E-Mail: rleng@ualberta.ca;
Tel.: +1-780-492-4985; Fax: +1-780-492-9974.
Received: 7 October 2012; in revised form: 22 November 2012 / Accepted: 27 November 2012 /
Published: 10 December 2012
Abstract: Neuronal survival and death of neurons are considered a fundamental
mechanism in the regulation of the nervous system during early development of the system
and in adulthood. Defects in this mechanism are highly problematic and are associated with
many neurodegenerative diseases. Because neuronal programmed death is apoptotic in
nature, indicating that apoptosis is a key regulatory process, the p53 family members
(p53, p73, p63) act as checkpoints in neurons due to their role in apoptosis. The complexity
of this system is due to the existence of different naturally occurring isoforms that have
different functions from the wild types (WT), vary
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