原创力文档virtual mutagenesis of the yeast cyclins genetic network reveals complex dynamics of transcriptional control networks酵母细胞周期蛋白基因网络的虚拟诱变揭示复杂的动态转录控制网络.pdfVIP
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virtual mutagenesis of the yeast cyclins genetic network reveals complex dynamics of transcriptional control networks酵母细胞周期蛋白基因网络的虚拟诱变揭示复杂的动态转录控制网络
Virtual Mutagenesis of the Yeast Cyclins Genetic
Network Reveals Complex Dynamics of Transcriptional
Control Networks
1,2 1
Eliska Vohradska , Jiri Vohradsky *
1 Laboratory of Bioinformatics, Institute of Microbiology ASCR v.v.i., Prague, Czech Republic, 2 Institute of Chemical Technology, Faculty of Food and Biochemical
Technology, Prague, Czech Republic
Abstract
Study of genetic networks has moved from qualitative description of interactions between regulators and regulated genes
to the analysis of the interaction dynamics. This paper focuses on the analysis of dynamics of one particular network – the
yeast cyclins network. Using a dedicated mathematical model of gene expression and a procedure for computation of the
parameters of the model from experimental data, a complete numerical model of the dynamics of the cyclins genetic
network was attained. The model allowed for performing virtual experiments on the network and observing their influence
on the expression dynamics of the genes downstream in the regulatory cascade. Results show that when the network
structure is more complicated, and the regulatory interactions are indirect, results of gene deletion are highly unpredictable.
As a consequence of quantitative behavior of the genes and their connections within the network, causal relationship
between a regulator and target gene may not be discovered by gene deletion. Without including the dynamics of the
system into the network, its functional properties cannot be studied and interpreted correctly.
Citation: Vohradska E, Vohradsky J (2011) Virtual Mutagenesis of the Yeast Cyclins Genetic Network Reveals Complex Dynamics of Transcriptional Control
Networks. PLoS ONE 6(4): e18827. doi:10.1371/journal.pone.001882
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