virulence characteristics and genetic affinities of multiple drug resistant uropathogenic escherichia coli from a semi urban locality in india多重耐药的毒性特征和遗传相似uropathogenic大肠杆菌从半在印度城市地区.pdfVIP

Virulence Characteristics and Genetic Affinities of Multiple Drug Resistant Uropathogenic Escherichia coli from a Semi Urban Locality in India 1. 2. 2. 2 2 Savita Jadhav , Arif Hussain , Savita Devi , Ashutosh Kumar , Sana Parveen , Nageshwari 1 3 3 2,4,5 Gandham , Lothar H. Wieler , Christa Ewers , Niyaz Ahmed * 1 Department of Microbiology, Dr. D. Y. Patil Medical College and Hospital, Pimpri, Pune, India, 2 Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India, 3 Veterinary Faculty, Institute for Microbiology and Epizootics, Freie Universitaet Berlin, Berlin, Germany, 4 Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia, 5 Institute of Life Sciences, University of Hyderabad Campus, Hyderabad, India Abstract Extraintestinal pathogenic Escherichia coli (ExPEC) are of significant health concern. The emergence of drug resistant E. coli with high virulence potential is alarming. Lack of sufficient data on transmission dynamics, virulence spectrum and antimicrobial resistance of certain pathogens such as the uropathogenic E. coli (UPEC) from countries with high infection burden, such as India, hinders the infection control and management efforts. In this study, we extensively genotyped and phenotyped a collection of 150 UPEC obtained from patients belonging to a semi-urban, industrialized setting near Pune, India. The isolates representing different clinical categories were analyzed in comparison with 50 commensal E. coli isolates from India as well as 50 ExPEC strains